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Activated factor V is a cofactor for the activation of factor XI by thrombin in plasma
The mechanism by which the intrinsic pathway of coagulation contributes to physiological hemostasis is enigmatic. Thrombin activates factor XI, a key zymogen in this pathway, which leads to increased thrombin generation. As thrombin-dependent activation of factor XI in vitro is relatively inefficien...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2889092/ https://ncbi.nlm.nih.gov/pubmed/20439754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004741107 |
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