Activated factor V is a cofactor for the activation of factor XI by thrombin in plasma

The mechanism by which the intrinsic pathway of coagulation contributes to physiological hemostasis is enigmatic. Thrombin activates factor XI, a key zymogen in this pathway, which leads to increased thrombin generation. As thrombin-dependent activation of factor XI in vitro is relatively inefficien...

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Autori principali: Maas, Coen, Meijers, Joost C. M., Marquart, J. Arnoud, Bakhtiari, Kamran, Weeterings, Cees, de Groot, Philip G., Urbanus, Rolf T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889092/
https://ncbi.nlm.nih.gov/pubmed/20439754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004741107
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