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Feedback activation of factor XI by thrombin does not occur in plasma

In this study, we tested the hypothesis that factor XI (FXI) activation occurs in plasma following activation of the extrinsic pathway by thrombin-mediated feedback activation. We used two different assays: (i) a direct measurement of activated FXI by ELISA and (ii) a functional assay that follows t...

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Autori principali: Pedicord, Donna L., Seiffert, Dietmar, Blat, Yuval
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1937556/
https://ncbi.nlm.nih.gov/pubmed/17652512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705566104
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