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Feedback activation of factor XI by thrombin does not occur in plasma

In this study, we tested the hypothesis that factor XI (FXI) activation occurs in plasma following activation of the extrinsic pathway by thrombin-mediated feedback activation. We used two different assays: (i) a direct measurement of activated FXI by ELISA and (ii) a functional assay that follows t...

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Detalhes bibliográficos
Main Authors: Pedicord, Donna L., Seiffert, Dietmar, Blat, Yuval
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1937556/
https://ncbi.nlm.nih.gov/pubmed/17652512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705566104
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