Kallikrein directly interacts with and activates Factor IX, resulting in thrombin generation and fibrin formation independent of Factor XI

Kallikrein (PKa), generated by activation of its precursor prekallikrein (PK), plays a role in the contact activation phase of coagulation and functions in the kallikrein-kinin system to generate bradykinin. The general dogma has been that the contribution of PKa to the coagulation cascade is depend...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Kearney, Katherine J., Butler, Juliet, Posada, Olga M., Wilson, Clare, Heal, Samantha, Ali, Majid, Hardy, Lewis, Ahnström, Josefin, Gailani, David, Foster, Richard, Hethershaw, Emma, Longstaff, Colin, Philippou, Helen
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7826336/
https://ncbi.nlm.nih.gov/pubmed/33397811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014810118
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