Hydrogen‐deuterium exchange mass spectrometry highlights conformational changes induced by factor XI activation and binding of factor IX to factor XIa

BACKGROUND: Factor XI (FXI) is a zymogen in the coagulation pathway that, once activated, promotes haemostasis by activating factor IX (FIX). Substitution studies using apple domains of the homologous protein prekallikrein have identified that FIX binds to the apple 3 domain of FXI. However, the mol...

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Détails bibliographiques
Publié dans:J Thromb Haemost
Auteurs principaux: Bar Barroeta, Awital, van Galen, Josse, Stroo, Ingrid, Marquart, J. Arnoud, Meijer, Alexander B., Meijers, Joost C. M.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2019
Sujets:
HAEMOSTASIS
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6916417/
https://ncbi.nlm.nih.gov/pubmed/31519061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14632
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