Hydrogen‐deuterium exchange mass spectrometry highlights conformational changes induced by factor XI activation and binding of factor IX to factor XIa

BACKGROUND: Factor XI (FXI) is a zymogen in the coagulation pathway that, once activated, promotes haemostasis by activating factor IX (FIX). Substitution studies using apple domains of the homologous protein prekallikrein have identified that FIX binds to the apple 3 domain of FXI. However, the mol...

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Bibliografiske detaljer
Udgivet i:J Thromb Haemost
Main Authors: Bar Barroeta, Awital, van Galen, Josse, Stroo, Ingrid, Marquart, J. Arnoud, Meijer, Alexander B., Meijers, Joost C. M.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
HAEMOSTASIS
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6916417/
https://ncbi.nlm.nih.gov/pubmed/31519061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14632
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