Basis for the Specificity and Activation of the Serpin Protein Z-dependent Proteinase Inhibitor (ZPI) as an Inhibitor of Membrane-associated Factor Xa

The serpin ZPI is a protein Z (PZ)-dependent specific inhibitor of membrane-associated factor Xa (fXa) despite having an unfavorable P1 Tyr. PZ accelerates the inhibition reaction ∼2000-fold in the presence of phospholipid and Ca(2+). To elucidate the role of PZ, we determined the x-ray structure of...

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Bibliographic Details
Main Authors: Huang, Xin, Dementiev, Alexey, Olson, Steven T., Gettins, Peter G. W.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888451/
https://ncbi.nlm.nih.gov/pubmed/20427285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.112748
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