Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes

BACKGROUND: The apoptotic speck-like protein containing a caspase recruitment domain (ASC) is the essential adaptor protein for caspase 1 mediated interleukin (IL)-1β and IL-18 processing in inflammasomes. It bridges activated Nod like receptors (NLRs), which are a family of cytosolic pattern recogn...

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Autores principales: Bryan, Nicole B, Dorfleutner, Andrea, Kramer, Sara J, Yun, Chawon, Rojanasakul, Yon, Stehlik, Christian
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887861/
https://ncbi.nlm.nih.gov/pubmed/20482797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-9255-7-23
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