Caspase-1 Protein Induces Apoptosis-associated Speck-like Protein Containing a Caspase Recruitment Domain (ASC)-mediated Necrosis Independently of Its Catalytic Activity

The adaptor protein, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), connects pathogen/danger sensors such as NLRP3 and NLRC4 with caspases and is involved in inflammation and cell death. We have found that ASC activation induced caspase-8-dependent apoptosis o...

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Main Authors: Motani, Kou, Kushiyama, Hiroko, Imamura, Ryu, Kinoshita, Takeshi, Nishiuchi, Takumi, Suda, Takashi
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2011
נושאים:
Cell Biology
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190783/
https://ncbi.nlm.nih.gov/pubmed/21832064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.286823
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