Dynamics of in vivo ASC speck formation

Activated danger or pathogen sensors trigger assembly of the inflammasome adaptor ASC into specks, large signaling platforms considered hallmarks of inflammasome activation. Because a lack of in vivo tools has prevented the study of endogenous ASC dynamics, we generated a live ASC reporter through C...

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Bibliografiske detaljer
Udgivet i:J Cell Biol
Main Authors: Kuri, Paola, Schieber, Nicole L., Thumberger, Thomas, Wittbrodt, Joachim, Schwab, Yannick, Leptin, Maria
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2017
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584180/
https://ncbi.nlm.nih.gov/pubmed/28701426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201703103
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