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The serum and cerebrospinal fluid pharmacokinetics of anakinra after intravenous administration to non-human primates

Anakinra improves the central nervous system manifestations of neonatal-onset multisystem inflammatory disease, which is mediated by IL-1β oversecretion. The cerebrospinal fluid (CSF) penetration of the IL-1 receptor antagonist anakinra was studied in rhesus monkeys after intravenous doses of 3 and...

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Bibliografiske detaljer
Main Authors: Fox, Elizabeth, Jayaprakash, Nalini, Pham, Tuyet-Hang, Rowley, Ayana, McCully, Cynthia L, Pucino, Frank, Goldbach-Mansky, Raphaela
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887614/
https://ncbi.nlm.nih.gov/pubmed/20421138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2010.03.022
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