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Administration of a Sigma Receptor Agonist Delays MCAO-Induced Neurodegeneration and White Matter Injury

Many pharmacological treatments for stroke have afforded protection in rodent models but failed to show efficacy in clinical trials. This discrepancy may be due to the lack of long-term functional studies. Previously, delayed administration of the sigma receptor agonist 1,3-di-o-tolylguanidine (DTG)...

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Autores principales: Leonardo, Christopher C., Hall, Aaron A., Collier, Lisa A., Green, Suzanne M., Willing, Alison E., Pennypacker, Keith R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885737/
https://ncbi.nlm.nih.gov/pubmed/20563232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12975-009-0005-9
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