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Modulation of the Active Complex Assembly and Turnover Rate by Protein–DNA Interactions in Cre–LoxP Recombination,
Cre promotes recombination at the 34 bp LoxP sequence. Substitution of a critical C-G base pair in LoxP with an A-T base pair, to give LoxAT, reduced Cre binding in vitro and abolished recombination in vivo. We demonstrated that LoxAT can be recombined in vitro. However, Cre discriminates against th...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2003
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2885442/ https://ncbi.nlm.nih.gov/pubmed/12779336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi0272306 |
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