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Vanadate-based transition-state analog inhibitors of Cre–LoxP recombination
Cre recombinase exchanges DNA strands at the LoxP recognition site via transphosphorylation reactions that involve pentacoordinate transition states. We demonstrate that meta-vanadate ion [Formula: see text] and appropriate DNA substrates assemble a transition-state analog-like complex in the Cre ac...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2913709/ https://ncbi.nlm.nih.gov/pubmed/12914783 |
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