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Vanadate-based transition-state analog inhibitors of Cre–LoxP recombination

Cre recombinase exchanges DNA strands at the LoxP recognition site via transphosphorylation reactions that involve pentacoordinate transition states. We demonstrate that meta-vanadate ion [Formula: see text] and appropriate DNA substrates assemble a transition-state analog-like complex in the Cre ac...

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Bibliografiske detaljer
Main Authors: Martin, Shelley S., Wachi, Shinichiro, Baldwin, Enoch P.
Format: Artigo
Sprog:Inglês
Udgivet: 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913709/
https://ncbi.nlm.nih.gov/pubmed/12914783
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