Carregant...

Multiple Levels of Affinity-Dependent DNA Discrimination in Cre-LoxP Recombination

Cre recombinase residue Arg259 mediates a canonical bidentate hydrogen-bonded contact with Gua27 of its LoxP DNA substrate. Substituting Cyt8-Gua27 with the three other basepairs, to give LoxAT, LoxTA, and LoxGC, reduced Cre-mediated recombination in vitro, with the preference order of Gua27 >Ade...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Gelato, Kathy A., Martin, Shelley S., Wong, Scott, Baldwin, Enoch P.
Format: Artigo
Idioma:Inglês
Publicat: 2006
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891539/
https://ncbi.nlm.nih.gov/pubmed/17014075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi0605235
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!