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Multiple Levels of Affinity-Dependent DNA Discrimination in Cre-LoxP Recombination

Cre recombinase residue Arg259 mediates a canonical bidentate hydrogen-bonded contact with Gua27 of its LoxP DNA substrate. Substituting Cyt8-Gua27 with the three other basepairs, to give LoxAT, LoxTA, and LoxGC, reduced Cre-mediated recombination in vitro, with the preference order of Gua27 >Ade...

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Detaylı Bibliyografya
Asıl Yazarlar: Gelato, Kathy A., Martin, Shelley S., Wong, Scott, Baldwin, Enoch P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2006
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2891539/
https://ncbi.nlm.nih.gov/pubmed/17014075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi0605235
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