Inflammation Anergy in Human Intestinal Macrophages Is Due to Smad-induced IκBα Expression and NF-κB Inactivation

Human intestinal macrophages contribute to tissue homeostasis in noninflamed mucosa through profound down-regulation of pro-inflammatory cytokine release. Here, we show that this down-regulation extends to Toll-like receptor (TLR)-induced cytokine release, as intestinal macrophages expressed TLR3–TL...

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Bibliografiske detaljer
Main Authors: Smythies, Lesley E., Shen, Ruizhong, Bimczok, Diane, Novak, Lea, Clements, Ronald H., Eckhoff, Devin E., Bouchard, Phillipe, George, Michael D., Hu, William K., Dandekar, Satya, Smith, Phillip D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885238/
https://ncbi.nlm.nih.gov/pubmed/20388715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.069955
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