Stromal Down-Regulation of Macrophage CD4/CCR5 Expression and NF-κB Activation Mediates HIV-1 Non-Permissiveness in Intestinal Macrophages

Tissue macrophages are derived exclusively from blood monocytes, which as monocyte-derived macrophages support HIV-1 replication. However, among human tissue macrophages only intestinal macrophages are non-permissive to HIV-1, suggesting that the unique microenvironment in human intestinal mucosa re...

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Detalhes bibliográficos
Main Authors: Shen, Ruizhong, Meng, Gang, Ochsenbauer, Christina, Clapham, Paul R., Grams, Jayleen, Novak, Lea, Kappes, John C., Smythies, Lesley E., Smith, Phillip D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102716/
https://ncbi.nlm.nih.gov/pubmed/21637819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002060
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