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Hypertrophic Cardiomyopathy Linked Mutation D145E Drastically Alters Calcium Binding By the C-domain of Cardiac Troponin C
The role of the C-domain sites of cardiac troponin C in the modulation of the calcium signal remains unclear. In this study we investigated the effects of hypertrophic cardiomyopathy linked mutations A8V, E134D and D145E in cardiac troponin C on the properties of the C-domain sites. The A8V mutation...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2883812/ https://ncbi.nlm.nih.gov/pubmed/20459070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100400h |
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