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Hypertrophic Cardiomyopathy Linked Mutation D145E Drastically Alters Calcium Binding By the C-domain of Cardiac Troponin C

The role of the C-domain sites of cardiac troponin C in the modulation of the calcium signal remains unclear. In this study we investigated the effects of hypertrophic cardiomyopathy linked mutations A8V, E134D and D145E in cardiac troponin C on the properties of the C-domain sites. The A8V mutation...

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Detalhes bibliográficos
Main Authors: Swindle, Nicholas, Tikunova, Svetlana B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883812/
https://ncbi.nlm.nih.gov/pubmed/20459070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100400h
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