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Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy
BACKGROUND: Resistance to BRAF inhibitors is an emerging problem in the melanoma field. Strategies to prevent and overcome resistance are urgently required. METHODS: The dynamics of cell signalling, BrdU incorporation and cell-cycle entry after BRAF inhibition was measured using flow cytometry and w...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2883709/ https://ncbi.nlm.nih.gov/pubmed/20531415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605714 |
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