Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy

BACKGROUND: Resistance to BRAF inhibitors is an emerging problem in the melanoma field. Strategies to prevent and overcome resistance are urgently required. METHODS: The dynamics of cell signalling, BrdU incorporation and cell-cycle entry after BRAF inhibition was measured using flow cytometry and w...

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Bibliographic Details
Main Authors:	Paraiso, K H T, Fedorenko, I V, Cantini, L P, Munko, A C, Hall, M, Sondak, V K, Messina, J L, Flaherty, K T, Smalley, K S M
Format:	Artigo
Language:	Inglês
Published:	Nature Publishing Group 2010
Subjects:	Translational Therapeutics
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2883709/ https://ncbi.nlm.nih.gov/pubmed/20531415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605714
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Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy

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