Spontaneous Ca Waves in Ventricular Myocytes from Failing Hearts Depend on Ca(2+)-calmodulin-dependent Protein Kinase II

Increased cardiac ryanodine receptor (RyR)-dependent diastolic SR Ca leak is present in heart failure and in conditions when adrenergic tone is high. Increasing Ca leak from the SR could result in spontaneous Ca wave (SCaW) formation. SCaWs activate the inward Na/Ca exchanger (NCX) current causing a...

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Hlavní autoři: Curran, Jerry, Brown, Kathy Hayes, Santiago, Demetrio J., Pogwizd, Steve, Bers, Donald M., Shannon, Thomas R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883657/
https://ncbi.nlm.nih.gov/pubmed/20353795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.03.013
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