Spontaneous Ca Waves in Ventricular Myocytes from Failing Hearts Depend on Ca(2+)-calmodulin-dependent Protein Kinase II

Increased cardiac ryanodine receptor (RyR)-dependent diastolic SR Ca leak is present in heart failure and in conditions when adrenergic tone is high. Increasing Ca leak from the SR could result in spontaneous Ca wave (SCaW) formation. SCaWs activate the inward Na/Ca exchanger (NCX) current causing a...

Full description

Saved in:
Bibliographic Details
Main Authors: Curran, Jerry, Brown, Kathy Hayes, Santiago, Demetrio J., Pogwizd, Steve, Bers, Donald M., Shannon, Thomas R.
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883657/
https://ncbi.nlm.nih.gov/pubmed/20353795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.03.013
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items