Novel HSP90 inhibitors, NVP-AUY922 and NVP-BEP800, radiosensitise tumour cells through cell-cycle impairment, increased DNA damage and repair protraction

BACKGROUND: Heat-shock protein 90 (Hsp90) has a crucial role in both the stabilisation and regulation of various proteins, including those related to radioresistance. Inhibition of Hsp90 may therefore provide a strategy for enhancing the radiosensitivity of tumour cells. This study explores the resp...

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Main Authors: Stingl, L, Stühmer, T, Chatterjee, M, Jensen, M R, Flentje, M, Djuzenova, C S
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
Teme:
Translational Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883148/
https://ncbi.nlm.nih.gov/pubmed/20502461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605683
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