The HSP90 inhibitor NVP-AUY922 potently inhibits non-small cell lung cancer growth

Heat shock protein 90 (HSP90) is involved in protein folding and functions as a chaperone for numerous client proteins, many of which are important in non-small cell lung cancer (NSCLC) pathogenesis. We sought to define preclinical effects of the HSP90 inhibitor NVP-AUY922 and identify predictors of...

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Autori principali: Garon, Edward B., Finn, Richard S., Hamidi, Habib, Dering, Judy, Pitts, Sharon, Kamranpour, Naeimeh, Desai, Amrita J., Hosmer, Wylie, Ide, Susan, Avsar, Emin, Jensen, Michael Rugaard, Quadt, Cornelia, Liu, Manway, Dubinett, Steven M., Slamon, Dennis J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681857/
https://ncbi.nlm.nih.gov/pubmed/23493311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0998
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