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Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders

BACKGROUND: Fatty acid amide hydrolase (FAAH) is an integral membrane enzyme that hydrolyzes the endocannabinoid anandamide and related amidated signaling lipids. Genetic or pharmacological inactivation of FAAH produces analgesic, anti-inflammatory, anxiolytic, and antidepressant phenotypes without...

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Main Authors: Ahn, Kay, Johnson, Douglas S., Cravatt, Benjamin F.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882713/
https://ncbi.nlm.nih.gov/pubmed/20544003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/17460440903018857
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