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Control of the SOST Bone Enhancer by PTH Using MEF2 Transcription Factors
Expression of the osteocyte-derived bone formation inhibitor sclerostin in adult bone requires a distant enhancer. We show that MEF2 transcription factors control this enhancer and mediate inhibition of sclerostin expression by PTH. INTRODUCTION: Sclerostin encoded by the SOST gene is a key regulato...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2882185/ https://ncbi.nlm.nih.gov/pubmed/17696759 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1359/jbmr.070804 |
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