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Genetic Evidence that SOST Inhibits WNT Signaling in the Limb
SOST is a negative regulator of bone formation and mutations in human SOST are responsible for sclerosteosis. In addition to high bone mass, sclerosteosis patients occasionally display hand defects, suggesting that SOST may function embryonically. Here we report that overexpression of SOST leads to...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2896299/ https://ncbi.nlm.nih.gov/pubmed/20359476 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2010.03.021 |
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