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Genetic Evidence that SOST Inhibits WNT Signaling in the Limb

SOST is a negative regulator of bone formation and mutations in human SOST are responsible for sclerosteosis. In addition to high bone mass, sclerosteosis patients occasionally display hand defects, suggesting that SOST may function embryonically. Here we report that overexpression of SOST leads to...

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Detalles Bibliográficos
Main Authors: Collette, Nicole M., Genetos, Damian, Murugesh, Deepa, Harland, Richard M., Loots, Gabriela G.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896299/
https://ncbi.nlm.nih.gov/pubmed/20359476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2010.03.021
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