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Genetic Evidence that SOST Inhibits WNT Signaling in the Limb

SOST is a negative regulator of bone formation and mutations in human SOST are responsible for sclerosteosis. In addition to high bone mass, sclerosteosis patients occasionally display hand defects, suggesting that SOST may function embryonically. Here we report that overexpression of SOST leads to...

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Bibliografski detalji
Glavni autori: Collette, Nicole M., Genetos, Damian, Murugesh, Deepa, Harland, Richard M., Loots, Gabriela G.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896299/
https://ncbi.nlm.nih.gov/pubmed/20359476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2010.03.021
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