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Sost, independent of the non-coding enhancer ECR5, is required for bone mechanoadaptation
Sclerostin (Sost) is a negative regulator of bone formation that acts upon the Wnt signaling pathway. Sost is mechanically regulated at both mRNA and protein level such that loading represses and unloading enhances Sost expression, in osteocytes and in circulation. The non-coding evolutionarily cons...
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| Pubblicato in: | Bone |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6673653/ https://ncbi.nlm.nih.gov/pubmed/27601226 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2016.09.001 |
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