Sost, independent of the non-coding enhancer ECR5, is required for bone mechanoadaptation

Sclerostin (Sost) is a negative regulator of bone formation that acts upon the Wnt signaling pathway. Sost is mechanically regulated at both mRNA and protein level such that loading represses and unloading enhances Sost expression, in osteocytes and in circulation. The non-coding evolutionarily cons...

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Detalhes bibliográficos
Publicado no:Bone
Main Authors: Robling, Alexander G., Kang, Kyung Shin, Bullock, Whitney A., Foster, William H., Murugesh, Deepa, Loots, Gabriela G., Genetos, Damian C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673653/
https://ncbi.nlm.nih.gov/pubmed/27601226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2016.09.001
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