Sost, independent of the non-coding enhancer ECR5, is required for bone mechanoadaptation

Sclerostin (Sost) is a negative regulator of bone formation that acts upon the Wnt signaling pathway. Sost is mechanically regulated at both mRNA and protein level such that loading represses and unloading enhances Sost expression, in osteocytes and in circulation. The non-coding evolutionarily cons...

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Dettagli Bibliografici
Pubblicato in:Bone
Autori principali: Robling, Alexander G., Kang, Kyung Shin, Bullock, Whitney A., Foster, William H., Murugesh, Deepa, Loots, Gabriela G., Genetos, Damian C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673653/
https://ncbi.nlm.nih.gov/pubmed/27601226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2016.09.001
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