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TGF-β Regulates Sclerostin Expression via the ECR5 enhancer
Wnt signaling is critical for skeletal development and homeostasis. Sclerostin (Sost) has emerged as a potent inhibitor of Wnt signaling and, thereby, bone formation. Thus, strategies to reduce Sclerostin expression may be used to treat osteoporosis or non-union fractures. Transforming growth factor...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3278543/ https://ncbi.nlm.nih.gov/pubmed/22155511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2011.11.016 |
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