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Prostaglandin E(2) Signals Through PTGER2 to Regulate Sclerostin Expression

The Wnt signaling pathway is a robust regulator of skeletal homeostasis. Gain-of-function mutations promote high bone mass, whereas loss of Lrp5 or Lrp6 co-receptors decrease bone mass. Similarly, mutations in antagonists of Wnt signaling influence skeletal integrity, in an inverse relation to Lrp r...

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Autors principals: Genetos, Damian C., Yellowley, Clare E., Loots, Gabriela G.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059227/
https://ncbi.nlm.nih.gov/pubmed/21436889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017772
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