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Hypoxia Decreases Sclerostin Expression and Increases Wnt Signaling in Osteoblasts
Mutations in sclerostin function or expression cause sclerosing bone dysplasias, involving decreased antagonism of Wnt/Lrp5 signaling. Conversely, deletion of the VHL tumor suppressor in osteoblasts, which stabilize HIF-α isoforms and thereby enables HIF-α/β-driven gene transcription, increases bone...
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| Hoofdauteurs: | , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2010
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2881162/ https://ncbi.nlm.nih.gov/pubmed/20336693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.22559 |
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