Hypoxia Decreases Sclerostin Expression and Increases Wnt Signaling in Osteoblasts

Mutations in sclerostin function or expression cause sclerosing bone dysplasias, involving decreased antagonism of Wnt/Lrp5 signaling. Conversely, deletion of the VHL tumor suppressor in osteoblasts, which stabilize HIF-α isoforms and thereby enables HIF-α/β-driven gene transcription, increases bone...

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Bibliografiska uppgifter
Huvudupphovsmän: Genetos, Damian C., Toupadakis, Chrisoula A., Raheja, Leah F., Wong, Alice, Papanicolaou, Savvas E., Fyhrie, David P., Loots, Gabriela G., Yellowley, Clare E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881162/
https://ncbi.nlm.nih.gov/pubmed/20336693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.22559
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