Chargement en cours...
Hypoxia Decreases Sclerostin Expression and Increases Wnt Signaling in Osteoblasts
Mutations in sclerostin function or expression cause sclerosing bone dysplasias, involving decreased antagonism of Wnt/Lrp5 signaling. Conversely, deletion of the VHL tumor suppressor in osteoblasts, which stabilize HIF-α isoforms and thereby enables HIF-α/β-driven gene transcription, increases bone...
Enregistré dans:
| Auteurs principaux: | , , , , , , , |
|---|---|
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2881162/ https://ncbi.nlm.nih.gov/pubmed/20336693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.22559 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|