Targeted deletion of Sost distal enhancer increases bone formation and bone mass

The Wnt antagonist Sost has emerged as a key regulator of bone homeostasis through the modulation of Lrp4/5/6 Wnt coreceptors. In humans, lack of Sclerostin causes sclerosteosis and van Buchem (VB) disease, two generalized skeletal hyperostosis disorders that result from hyperactive Wnt signaling. U...

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Autors principals: Collette, Nicole M., Genetos, Damian C., Economides, Aris N., Xie, LiQin, Shahnazari, Mohammad, Yao, Wei, Lane, Nancy E., Harland, Richard M., Loots, Gabriela G.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435175/
https://ncbi.nlm.nih.gov/pubmed/22886088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207188109
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