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Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition

The rapid replication of HIV-1 and the errors made during viral replication, cause the virus to evolve rapidly in patients, making the problems of vaccine development and drug therapy particularly challenging. In the absence of an effective vaccine, drugs are the only useful treatment. Anti-HIV drug...

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Main Authors: Sarafianos, Stefan G., Marchand, Bruno, Das, Kalyan, Himmel, Daniel, Parniak, Michael A., Hughes, Stephen H., Arnold, Eddy
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881421/
https://ncbi.nlm.nih.gov/pubmed/19022262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.10.071
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