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Recognition of beta-structural motifs using hidden Markov models trained with simulated evolution

Motivation: One of the most successful methods to date for recognizing protein sequences that are evolutionarily related, has been profile hidden Markov models. However, these models do not capture pairwise statistical preferences of residues that are hydrogen bonded in β-sheets. We thus explore met...

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Detalhes bibliográficos
Main Authors: Kumar, Anoop, Cowen, Lenore
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881384/
https://ncbi.nlm.nih.gov/pubmed/20529918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btq199
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