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Recognition of beta-structural motifs using hidden Markov models trained with simulated evolution

Motivation: One of the most successful methods to date for recognizing protein sequences that are evolutionarily related, has been profile hidden Markov models. However, these models do not capture pairwise statistical preferences of residues that are hydrogen bonded in β-sheets. We thus explore met...

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Autori principali: Kumar, Anoop, Cowen, Lenore
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881384/
https://ncbi.nlm.nih.gov/pubmed/20529918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btq199
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