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Augmented training of hidden Markov models to recognize remote homologs via simulated evolution

Motivation: While profile hidden Markov models (HMMs) are successful and powerful methods to recognize homologous proteins, they can break down when homology becomes too distant due to lack of sufficient training data. We show that we can improve the performance of HMMs in this domain by using a sim...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kumar, Anoop, Cowen, Lenore
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2732314/
https://ncbi.nlm.nih.gov/pubmed/19389731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btp265
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