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Thermodynamic Characterization of DNA with 3-Deazaadenine and 3-Methyl-3-Deazaadenine Substitutions: The Effect of Placing a Hydrophobic Group in the Minor Groove of DNA

In many high-resolution structures of DNA there are ordered waters associated with the floor of the minor groove and extending outward in several layers. It is thought that this hydration structure, along with cations, reduces the Coulombic repulsion of the interstrand phosphates. In previous studie...

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Autores principales: Ganguly, Manjori, Wang, Ruo-Wen, Marky, Luis A., Gold, Barry
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880643/
https://ncbi.nlm.nih.gov/pubmed/20469878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp101004k
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