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Transforming Growth Factor-β Signaling Curbs Thymic Negative Selection Promoting Regulatory T Cell Development
Thymus-derived naturally occurring regulatory T cells (nTregs) are necessary for immunological self-tolerance. nTreg development is instructed by the T cell receptor, and can be induced by agonist antigens that trigger T cell negative selection. How T cell deletion is regulated so that nTregs are ge...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2880228/ https://ncbi.nlm.nih.gov/pubmed/20471291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.04.012 |
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