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Transforming Growth Factor-β Signaling Curbs Thymic Negative Selection Promoting Regulatory T Cell Development

Thymus-derived naturally occurring regulatory T cells (nTregs) are necessary for immunological self-tolerance. nTreg development is instructed by the T cell receptor, and can be induced by agonist antigens that trigger T cell negative selection. How T cell deletion is regulated so that nTregs are ge...

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Detalhes bibliográficos
Main Authors: Ouyang, Weiming, Beckett, Omar, Ma, Qian, Li, Ming O.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880228/
https://ncbi.nlm.nih.gov/pubmed/20471291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.04.012
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