Defective DNA Replication Impairs Mitochondrial Biogenesis In Human Failing Hearts Karamanlidis: Mitochondrial biogenesis in human heart failure

RATIONALE: Mitochondrial dysfunction plays a pivotal role in the development of heart failure. Animal studies suggest that impaired mitochondrial biogenesis due to down-regulation of the PGC-1 transcriptional pathway is integral of mitochondrial dysfunction in heart failure. OBJECTIVE: The study sou...

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Main Authors: Karamanlidis, Georgios, Nascimben, Luigino, Couper, Gregory S., Shekar, Prem S., Monte, Federica del, Tian, Rong
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880225/
https://ncbi.nlm.nih.gov/pubmed/20339121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.212753
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