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Promoting PGC-1α-driven mitochondrial biogenesis is detrimental in pressure-overloaded mouse hearts
Mitochondrial dysfunction in animal models of heart failure is associated with downregulation of the peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α pathway. To test whether PGC-1α is an appropriate therapeutic target for increasing mitochondrial biogenesis and improving function i...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Physiological Society
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4217009/ https://ncbi.nlm.nih.gov/pubmed/25172896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00280.2014 |
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