Promoting PGC-1α-driven mitochondrial biogenesis is detrimental in pressure-overloaded mouse hearts

Mitochondrial dysfunction in animal models of heart failure is associated with downregulation of the peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α pathway. To test whether PGC-1α is an appropriate therapeutic target for increasing mitochondrial biogenesis and improving function i...

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Autors principals: Karamanlidis, Georgios, Garcia-Menendez, Lorena, Kolwicz, Stephen C., Lee, Chi Fung, Tian, Rong
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2014
Matèries:
Energetics and Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217009/
https://ncbi.nlm.nih.gov/pubmed/25172896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00280.2014
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