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Defective DNA Replication Impairs Mitochondrial Biogenesis In Human Failing Hearts Karamanlidis: Mitochondrial biogenesis in human heart failure
RATIONALE: Mitochondrial dysfunction plays a pivotal role in the development of heart failure. Animal studies suggest that impaired mitochondrial biogenesis due to down-regulation of the PGC-1 transcriptional pathway is integral of mitochondrial dysfunction in heart failure. OBJECTIVE: The study sou...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2880225/ https://ncbi.nlm.nih.gov/pubmed/20339121 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.212753 |
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