Elamipretide Improves Mitochondrial Function in the Failing Human Heart

Negative alterations of mitochondria are known to occur in heart failure (HF). This study investigated the novel mitochondrial-targeted therapeutic agent elamipretide on mitochondrial and supercomplex function in failing human hearts ex vivo. Freshly explanted failing and nonfailing ventricular tiss...

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Vydáno v:JACC Basic Transl Sci
Hlavní autoři: Chatfield, Kathryn C., Sparagna, Genevieve C., Chau, Sarah, Phillips, Elisabeth K., Ambardekar, Amrut V., Aftab, Muhammad, Mitchell, Max B., Sucharov, Carmen C., Miyamoto, Shelley D., Stauffer, Brian L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2019
Témata:
CLINICAL RESEARCH
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6488757/
https://ncbi.nlm.nih.gov/pubmed/31061916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2018.12.005
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