Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure

Mitochondrial respiratory dysfunction is linked to the pathogenesis of multiple diseases including heart failure but the specific mechanisms for this link remain largely elusive. We modeled the impairment of mitochondrial respiration by inactivation of the Ndufs4 gene, a protein critical for Complex...

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Main Authors: Karamanlidis, Georgios, Lee, Chi Fung, Garcia-Menendez, Lorena, Kolwicz, Stephen C., Suthammarak, Wichit, Gong, Guohua, Sedensky, Margaret M., Morgan, Philip G., Wang, Wang, Tian, Rong
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779647/
https://ncbi.nlm.nih.gov/pubmed/23931755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.07.002
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