SUMO-Specific Protease 2 Is Essential for Suppression of Polycomb Group Proteins Mediated Gene Silencing During Embryonic Development

SUMO-specific protease 2 (SENP2) has a broad de-SUMOylation activity in vitro. However, the biological function of SENP2 is largely unknown. Here, we show that deletion of SENP2 gene in mouse causes defects in the embryonic heart and reduces the expression of Gata4 and Gata6, which are essential for...

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Main Authors: Kang, Xunlei, Qi, Yitao, Zuo, Yong, Wang, Qi, Zou, Yanqiong, Schwartz, Robert J., Cheng, Jinke, Yeh, Edward T.H.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879644/
https://ncbi.nlm.nih.gov/pubmed/20417598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.03.005
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