Targeting EGFR Induced Oxidative Stress by PARP1 Inhibition in Glioblastoma Therapy

Despite the critical role of Epidermal Growth Factor Receptor (EGFR) in glioblastoma pathogenesis [1], [2], EGFR targeted therapies have achieved limited clinical efficacy [3]. Here we propose an alternate therapeutic strategy based on the conceptual framework of non-oncogene addiction [4], [5]. A d...

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Autors principals: Nitta, Masayuki, Kozono, David, Kennedy, Richard, Stommel, Jayne, Ng, Kimberly, Zinn, Pascal O., Kushwaha, Deepa, Kesari, Santosh, Furnari, Frank, Hoadley, Katherine A., Chin, Lynda, DePinho, Ronald A., Cavenee, Webster K., D'Andrea, Alan, Chen, Clark C.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879424/
https://ncbi.nlm.nih.gov/pubmed/20532243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010767
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