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Molecular determinants of coupling between the domain III voltage-sensor and pore of a sodium channel
In a voltage-dependent sodium channel, the activation of voltage-sensors upon depolarization leads to the opening of pore gates. To elucidate the principles underlying this conformational coupling, we investigated a putative gating interface in domain III of the sodium channel using voltage-clamp fl...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2879147/ https://ncbi.nlm.nih.gov/pubmed/20118934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1749 |
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