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Local Anesthetics Disrupt Energetic Coupling between the Voltage-sensing Segments of a Sodium Channel
Local anesthetics block sodium channels in a state-dependent fashion, binding with higher affinity to open and/or inactivated states. Gating current measurements show that local anesthetics immobilize a fraction of the gating charge, suggesting that the movement of voltage sensors is modified when a...
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| Asıl Yazarlar: | , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
The Rockefeller University Press
2009
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2606943/ https://ncbi.nlm.nih.gov/pubmed/19088384 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200810103 |
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