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Domain IV voltage-sensor movement is both sufficient and rate limiting for fast inactivation in sodium channels
Voltage-gated sodium channels are critical for the generation and propagation of electrical signals in most excitable cells. Activation of Na(+) channels initiates an action potential, and fast inactivation facilitates repolarization of the membrane by the outward K(+) current. Fast inactivation is...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3727307/ https://ncbi.nlm.nih.gov/pubmed/23858005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201310998 |
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